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Professor Bush is the Australian Research Council Federation Fellow at the Mental Health Research Institute of Victoria (Australia) and a co-founding scientist of Prana.
Professor Bush studies the major proteins implicated in Alzheimer�s disease that aggregate to cause plaques. Copper/zinc-binding proteins, whose physiochemical properties (e.g. solubility), are profoundly influenced by interaction with metal ions. Dr. Bush�s lab has developed new drugs based on metals theory that are being tested in the clinic.
Professor Bush�s lab also explores the causes of severe oxidative stress in the brain as it relates to Alzheimer�s disease, as well as the relationship between amyloid deposition in the brain (the typical pathology of Alzheimer�s disease) and oxidation injury. | 