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Dr. H. Bryan Brewer Jr. has been a member of our Scientific Advisory Board since March 2001 and has served as a member of the Company's Board of Directors since October 2002. In May 2005 he was appointed Vice Chairman of the Board and engaged as Chief Scientific Director of the Company. In April 2005 Dr. Brewer became the Director of Lipoprotein and Atherosclerosis Research at the Cardiovascular Research Institute MedStar Research Institute Washington Hospital Center in Washington D.C. From 1976 to March 2005 Dr. Brewer was the Chief of the Molecular Disease Branch at the National Heart Lung and Blood Institute National Institutes of Health ("NIH") in Bethesda Maryland. His research led to the first published sequences for human plasma apolipoproteins the initial determination of plasma apolipoproteins metabolism in normal and hyperlipidemic individuals and the identification of multiple gene defects leading to genetic dyslipoproteinemias. More recently Dr. Brewer pioneered the use of transgenic mice and rabbits as well as recombinant adenovirus vectors to identify genes that modulate lipoprotein metabolism and the development of atherosclerosis. Dr. Brewer has been the recipient of the JD Lane Investigator Award from the Public Health Service the Heinrich Wieland Prize from the Federal Republic of Germany and the Public Health Service Commendation Meritorious Service and Distinguished Service medals from the NIH. He has served as a member of the Board of National Cholesterol Education Program which established U.S. treatment guidelines for patients with hyperlipidemia. He has published more than 400 original reports and 70 reviews and book chapters on the subjects of genetic dyslipoproteinemias lipoprotein metabolism and atherosclerosis. Dr. Brewer earned his Bachelor of Science from Johns Hopkins University and his Doctorate of Medicine from Stanford University School of Medicine. He completed his internship and residency training in internal medicine at Massachusetts General Hospital in Boston Massachusetts. | 