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Professor, Department of Biomedical Engineering
Department of Electrical and Computer Engineering
Recently inducted into AIMBE for outstanding contributions advancing basic theory and
practice in biomedical optics, including optical biopsy, interstitial laser thermotherapy, and
optical pharmacokinetics
Research Interests:
Medical applications of optics, lasers and spectroscopy, Biomedical Optics and Biophotonics
Biomolecular dynamics
Applied spectroscopy, especially to biomedical problems
Nonlinear optics, quantum electronics and laser physics
Current Research:
The core theme of biomedical optics/photonics is minimally invasive optical diagnostics and therapeutics. The current
national trend in health care is a growing emphasis on preventive medicine, early diagnosis, reduced invasiveness of
procedures, outpatient procedures - in short, an overall reduction in the cost of providing health care. Minimally
invasive techniques address such aims in addition to providing significant patient benefits. Current developments in
optical technologies are rapidly increasing the technical options available. Moreover, the ongoing growth in use of
endoscopes and laparoscopes in medicine makes this theme very timely. Some components of Dr. Bigios current research:
Advanced spectroscopic technologies for tissue diagnosis
Noninvasive measurement of drug concentrations in tissue
Interstitial laser thermotherapy and photodynamic therapy
Computational methods for modeling optical transport in tissue
Multi-capability endoscopic and laparoscopic instruments
Selected Recent Publications:
1. J. Bigio, S.C Bown, G. Briggs, S. Lakhani, D. Pickard, P.M. Ripley, I.G. Rose and C. Saunders �Diagnosis of breast
cancer using elastic-scattering spectroscopy:
preliminary clinical results Journal of Biomedical Optics 5: 221-228 (2000)
Judith R. Mourant, Tamara M. Johnson, Gerrit Los, frying J. Bigio Noninvasive measurement of chemotherapy drug
concentrations in tissue: preliminary demonstrations of in vivo measurements Journal of Physics in Medicine and
Biology
44: 1397-1417 (1999)
Irving 3. Bigio, Judith R. Mourant Ultraviolet and visible spectroscopies for tissue diagnostics: fluorescence
spectroscopy and elastic-scattering spectroscopy Journal of Physics in Medicine and Biology 42: 803-814(1997)
A.H. Hielscher, J.R. Mourant, I. J. Bigio Influence of particle size and concentration on the diffuse backscattering of
polarized light from tissue phantoms and biological cell suspensions Applied Optics 36: 125-135 (1997)
J. R. Mourant, T. Fuselier, J. Boyer, T. Johnson, I. 3. Bigio Predictions and measurements of scattering and
absorption over broad wavelength ranges in tissue phantoms Applied Optics 36: 949-957 (1997)
J.R. Mourant, J. Boyer, A. Hielscher, I.J. Bigio Influence of the scattering phase fi.inction on light transport
measurements in turbid media performed with small source- detector separations Optics Letters 21: pp.546-548
(1996) | 