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Dr. SakkuBai Naidu is a research scientist at the Kennedy Krieger Institute. She is also a Professor in the Departments of Neurology and Pediatrics at the Johns Hopkins University School of Medicine.
Biographical Sketch:
Dr. Naidu received her undergraduate and medical training at Madras Medical College in India, graduating in 1962. She served internships and residencies in Pediatrics at hospitals in Madras and in Brooklyn before accepting a fellowship in Pediatric Neurology at Albert Einstein College of Medicine in the Bronx. She worked in hospitals in Chicago at the University of Illinois and Loyola University in Maywood, IL. In 1983 she trained in Neonatal EEG/Neurology at Port Royal Hospital in Paris. She came to Hopkins in 1985 as a Joseph P. Kennedy Jr. Foundation Scholar. Dr. Naidu works as a pediatric neurologist at KKI, where she directs KKI�s Neurogenetics Unit.
Dr. Naidu is a member of the American Academy of Neurology, Child Neurology Society, American Neurological Association, International Child Neurology Society, Society for Inherited Metabolic Disorders, Society for Neuroscience, Neurological Society of India, and the American Association for the Advancement of Science.
Research Summary:
Rett syndrome (RS), a neurodevelopmental disorder predominantly affecting females, is characterized by a period of apparent normal development followed by loss of developmental skills, primarily expressive language and purposeful hand use. It is associated with stereotyped hand movements, gait disturbance, seizures, irregular respiration, and deceleration of head growth. The genetic defect causing the disorder was mapped to chromosome xq28 and identified to be secondary to mutations in the MeCP2 gene.
Dr. Naidu is a trained pediatrician and neurologist with special interest in developmental and neurogenetic disorders affecting children and adults. Combining careful clinical analysis with technological advances in neuroimaging, genetics and neuroscience, Dr. Naidu is able to accurately characterize neurogenetic disorders. Her activities are at the interface between clinical neurology and basic sciences. Work involving this interface provides a unique opportunity to understand the developing brain, the biological basis of disease, and to develop new strategies for prevention and therapy.
Dr. Naidu and colleagues, in addition to having extensively studied the pathogenesis of RS, proposed a chemical explanation for why older girls with the disorder have fewer seizures, and experience less psychomotor regression than younger ones. In her work with other neurodegenerative disorders, particularly those associated with abnormalities of the white matter of the brain, Dr. Naidu and colleagues have tested criteria for in vivo MR imaging diagnosis of Alexander's disease, usually eliminating the need for a brain biopsy to obtain a definitive diagnosis. She has also demonstrated a novel MRI manifestation of adult Krabb� disease. Dr. Naidu works with unclassified leukoencephalopathies, and has identified new categories of disorders in which genetic studies are being pursued.
RESEARCH PARTICIPANTS NEEDED:Adrenomyeloneuropathy (AMN) Research Study
Recent Publications/Presentations:
Naidu S, 1997. Rett Syndrome: A disorder affecting early brain growth. Ann Neurol 42 (1): 3-10.
Blue ME, Naidu S, Johnston MV, 1999. Development of Amino Acid Receptors in Frontal Cortex from Girls with Rett Syndrome. Ann Neurol 45 (4): 541-545.
Farina L, Bizzi A, Finocchiaro G, Pareyson D, Sghirlanzoni A, Bertagnolio B, Savoiardo M, Naidu S, Singhal BS, Wenger DA, 2000. MR imaging and proton MR spectroscopy in adult Krabb� disease. Am J Neuroradiol 21:1478-1482.
van der Knaap MS, Naidu S, Breiter SN, Blaser S, Stroink H, Springer S, Begeer JC, van Coster R, Barth PG, Thomas NH, 2001. Alexander's disease: Diagnosis with MR Imaging. Am J Neuroradiol 22:541-552.
Gorospe JR, Naidu S, Johnson AB, Puri V, Raymond GV, Jenkins SD, Pedersen RC, Lewis D, Knowles P, Fernandez R, DeVivo D, van der Knaap MS, Messing A, Brenner M, Hoffman EP, 2002. Molecular findings in symptomatic and pre-symptomatic Alexander disease patients. Neurology ;58:1494-1500.
Hoffbuhr K, Devaney JM, LaFleur B, Sirianni MS, Scacheri MS, Giron J, Schuette J, Innis J, Marino M, Philippart M, Narayanan V, Umansky R, Kronn D, Hoffman EP, Naidu S, 2001. MeCP2 mutations in children with and without the phenotype of Rett syndrome. Neurology 56;1486-1495. |
